With the advancement of in vitro fertilization and genetic testing technology now the genetic diagnosis is possible at the embryo stage. This testing helps to identify genetically normal embryos.
Pre-implantation genetic testing – PGT-A tests the embryo before its implantation in the uterus and therefore before the onset of pregnancy.
Genetic testing can be for various reasons.
Pre-implantation Genetic testing for aneuploidy. It is also called PGS (Pre-implantation Genetic Screening). Genetic abnormalities of embryos like change in gene number (aneuploidy) is a major cause of IVF failure and miscarriage. PGT-A detects normal and abnormal embryos. We select embryos without aneuploidy for embryo transfer for improving implantation chances and reduce miscarriage risk.
Increasing female age can increase the chance of downтАЩs syndrome in the foetus. DownтАЩs syndrome is a non-lethal genetic abnormality causing mental and physical disability. PGT-A can prevent downтАЩs syndrome.
PGT – A is indicated in patients of advanced female age, repeated IVF failure, severely reduced sperm count or motility and recurrent miscarriage.
PGT тАУ A is the best treatment option for fastest success in IVF to minimize тАШTime to pregnancyтАЭ.
Preimplantation Genetic testing for monogenic disorders. It is also called PGD (Pre-implantation Genetic Diagnosis).
When a genetic disease or carrier status is identified in parents. PGT-M helps to prevent transmission of the genetic condition to the foetus/offspring. PGT-M can help when there is a defined genetic mutation, as in monogenic disorders.
Monogenic disorders are disorders due to a problem in a single gene only. PGT-M can help diagnose disorders such as Beta-thalassemia, sickle cell disease and spinal muscular atrophy type 1 haemophilia, Duchenne muscular dystrophy etc., at the embryo stage. We can prevent transmission of practically every disease or defect which can be inherited by a child from a mother or father if we know the defective gene responsible for that defect. This list is very long.
Pre-implantation Genetic Testing for Structural Rearrangements. It is performed when there are genetic rearrangements in the wife and or husband. This can lead to a higher incidence of genetic abnormalities in the embryo. PGT-SR helps to identify these abnormalities. Thus, improving IVF success and reducing chances of miscarriage.
Some genetic conditions like thalassemia can only be cured permanently by bone marrow transplant or other similar treatment. For this, HLA matched donor is required. Getting a matching donor is extremely difficult. The couples who already have an affected child can conceive a not affected child, and that too a matching donor for the affected sibling.
IVF process is a per standard protocol. When the embryos are ready, they can be biopsied, and genetic sample collection can be done on Day 3 or Day 5. For collecting cells for genetic analysis, a Laser is used to make a small opening in the outer wall of the embryo. A suction pipette gently sucks one or more cells from the embryo. Cells are sent for genetic analysis. Embryos are totipotent at this stage, so removing these cells will not harm the embryo.
BFI is pioneers of PGT technology in India.
BFI delivers PGT-A results within a day. Thanks to our precise technique and most advanced genetic testing laboratory support with all available genetic testing technologies like NGS, Array CGH and more. We have mastered meticulous execution, logistics too. This facilitates fresh transfer even in PGT A cycles. Early results also avoid the unnecessary cost of freezing abnormal embryos.
BFI has treated a very wide variety of genetic disorders, including some of the very rare diseases, also like the complete absence of hair on the body.
BFI successfully used the technology of PGD + HLA matching for thalassemia and helped a couple conceive a normal donor sibling (2021)! Two more on the way to deliver. A very few cases have recorded the world over.
Bavishi Fertility Institute offers advanced, accurate, and ethical PGT services in Ahmedabad, ensuring the best outcomes for fertility and genetic disorder prevention. Trust BFI for personalized care and successful family planning.
This question explores any possible negative impacts or risks associated with the PGT process.
This addresses how adding PGT to an IVF cycle might impact the overall cost and financial considerations.
This question seeks to clarify if there are specific age or other criteria that determine eligibility for PGT.
This focuses on comparing the success rates of IVF with and without PGT.
This covers the options available if none of the embryos pass the genetic testing.
This explores whether PGT is useful for genetic conditions that develop after birth rather than inherited conditions.
This question seeks to understand the criteria and process for selecting embryos for implantation after PGT results.
This addresses the specific genetic tests used and their reliability in detecting abnormalities.
This examines whether PGT is applicable for single-gene disorders if thereтАЩs no known family history or carrier status.
This considers the potential emotional and psychological effects on individuals or couples going through PGT.
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