Ovarian Rejuvenation
Rejuvenating the ovaries for increasing their egg-producing capacity is called “Ovarian RejuvenationтАЭ.
Ovarian function is the most crucial part of IVF treatment. Good ovarian function, more healthy eggs, more chance of good quality embryos, more chance of embryo selection and more chances of freezing the extra embryos.
Unfortunately, some women have ovaries that start losing their function earlier than expected. Some women try to conceive at a later age; here, there is a naturally expected decline in the functional capacity of ovaries. Some women want to conceive with their own eggs even after they have achieved menopause, where ovaries have already stopped producing eggs.
Patients with very low AMH and increasing FSH reports, patients who have a poor response to IVF are good candidates for ovarian rejuvenation.
Normally an aggressive stimulation protocol is tried to get maximum eggs per treatment cycle. However, it requires a very high dose of drugs, more expense, and still a very poor yield of eggs.
A more logical solution is to increase the functioning capacity of ovaries. IsnтАЩt it?
PRP тАУ Platelet Rich Plasma therapy
Platelets are very rich in cytokines and many other growth-promoting factors. Activation and enrichment of platelets make them even more capable functionally. Injection of concentrated, activated, enriched PRP can enhance the egg-producing capacity of the ovaries.
BFI has achieved many natural pregnancies also in these very poor pregnancy chance couples.
We can expect ovaries to be more responsive to natural or outside stimuli. It can be expected to get a better response in IVF stimulation as well.
PROCEDURE
- The procedure is very simple and safe.
- The blood is collected from the patient.
- It is processed in our own laboratory to separate platelets.
Special treatment is done to enrich the preparation and make it more effective.
The prepared PRP is injected in both ovaries in ultrasound guidance with a very thin needle.
ADVANTAGES
It is prepared from the patients own blood, so no outside drug or material is injected into the body. It is a very simple & relatively inexpensive process. The effect can last for a long time, not only for one treatment cycle.
DISADVANTAGES AND LIMITATIONS
- It is not a sure shot procedure. The result is variable in different patients.
- It is not a permanent cure.
- The beneficial effect reduces over a period of time.
Stem cell Therapy
Stem cells are the patientsтАЩ own cells that have the capacity to transform themselves into different body cells. They are also used for ovarian rejuvenation.
ADVANTAGES
Most commonly, stem cells are derived from patients own body, so there is no risk of transmission of infection. The procedure is relatively very safe. Effective in many cases.
DISADVANTAGES AND LIMITATIONS
Stem cell harvesting is a more invasive process. It is more expensive than PRP. Whether it has better results compared to simpler options like PRP is not proven. Results are variable; all treated patients may not have improvement.
PROCEDURE
Most procedures use stem cells derived from bone marrow, which is collected from the hip bone. Prepared stem cells are injected into the ovaries.
Step-by-Step Process of Ovarian Rejuvenation Therapy
Ovarian Rejuvenation Therapy is an advanced fertility treatment aimed at improving ovarian function and promoting egg production, particularly in women with reduced ovarian reserve or age-related infertility. HereтАЩs a step-by-step guide to how this therapy works:
1. Initial Consultation and Assessment
- The process begins with a thorough medical consultation with a fertility specialist. The doctor will review your medical history, hormone levels, and perform necessary fertility tests, such as ultrasound and blood tests.
- Tests like Anti-M├╝llerian Hormone (AMH) and Follicle Stimulating Hormone (FSH) levels help determine ovarian reserve and readiness for treatment.
2. Blood Collection and Preparation (PRP Method)
- A small sample of your blood is drawn. The blood is then processed using a technique called Platelet-Rich Plasma (PRP) therapy.
- In this step, the blood is placed in a centrifuge to separate the platelets and growth factors that promote tissue healing and regeneration.
3. Preparation for PRP Injection
- Once the PRP is prepared, the patient undergoes a procedure that is similar to egg retrieval used in IVF.
- Local anesthesia or mild sedation may be used to ensure comfort during the procedure.
4. Injection of PRP into the Ovaries
- Using ultrasound guidance, the PRP is injected directly into the ovaries. The growth factors in PRP are believed to stimulate the ovaries to improve their function and potentially produce more eggs.
- This part of the procedure is minimally invasive, and the patient can often go home the same day.
5. Post-Treatment Monitoring
- After the PRP injection, you will be monitored over the next few weeks or months to assess ovarian response. Blood tests will be conducted to check hormone levels and monitor ovarian activity.
- Ultrasound scans may be performed to track the development of follicles in the ovaries.
6. Follow-Up and Fertility Treatment
- If ovarian function improves and eggs are produced, you may proceed with fertility treatments such as In Vitro Fertilization (IVF) or Intrauterine Insemination (IUI).
- The doctor will design a personalized fertility plan based on your response to the therapy.
7. Possible Additional Treatments
- Some women may need a second round of PRP injections depending on the initial response. Regular monitoring will guide whether further treatments are necessary.
8. Success Evaluation
- Success is evaluated based on the improvement in hormone levels, increased follicle count, and overall ovarian function.
- If pregnancy is achieved naturally or through assisted reproductive techniques, ongoing monitoring will ensure the health of the pregnancy.
Drug therapy
Androgen substitutes
Egg development cycle is for approximately 3 months. Of this development of first two months is under control of androgens. Androgens are considered to be predominantly male hormones, but their function in female egg development is also crucial. Various such medicines or nutritional supplements are tried. None of this shows good results when the medical studies are well designed. One such drug is testosterone gel applied to the skin. However, it requires medical supervision. The more popular supplement is DHEA.
DHEA (Dehydroepiandrosterone)
DHEA is found in many foods naturally. Adrenal glands also secrete it. DHEA is given for 3 to 6 months with the hope to increase androgen level in the ovary. After the therapy, ovaries are expected to have more egg number. Our take is that it shows only marginal benefit if any; you should not delay your treatment for DHEA, as delay may do more harm than good.
Nutritional supplements
Various foods and supplements with anti-ageing- antioxidant properties are used. Common are Coenzyme Q10 (ubiquinone/ubiquinone), Vitamin D, folic acid etc.
The percentage of patients who benefit from medical treatment is low.
The major disadvantage is time wasted in waiting for improvement, which may not occur but may reduce fertility тАУ ovarian reserve.
The best policy is to various methods of ovarian rejuvenation along with immediate IVF, in our opinion. Avoid wasting any time.
Why Choose Bavishi Fertility Institute for Ovarian Rejuvenation Treatment?
- Experienced Fertility Experts: Led by renowned fertility specialists with years of experience in advanced treatments, including ovarian rejuvenation.
- Cutting-Edge Technology: Equipped with state-of-the-art technology and facilities to perform the latest fertility procedures, ensuring the highest standard of care.
- Personalized Treatment Plans: Every patient receives a customized treatment plan based on their specific medical history, fertility needs, and response to therapies.
- Proven Success Rates: Bavishi Fertility Institute has a strong track record of success, consistently ranked among the top IVF centers in Ahmedabad and Gujarat.
- Comprehensive Care: Offers a full range of fertility services under one roof, including diagnostic tests, ovarian rejuvenation, and IVF, ensuring seamless care from start to finish.
- International Expertise: The team stays updated with global advancements in fertility treatments and integrates the latest techniques to improve outcomes.
- Comfortable and Supportive Environment: Patient-centric approach that focuses on emotional well-being and provides continuous support throughout the fertility journey.
- Transparent and Ethical Practices: Clear communication, cost transparency, and ethical practices, making sure patients are fully informed at every stage.
- Convenient Location: Centrally located in Ahmedabad, Bavishi Fertility Institute offers easy access for patients not only from all over Gujarat, including Surat, but also from major cities like Mumbai and Delhi, making it a convenient choice for those seeking advanced fertility treatments..
Choosing Bavishi Fertility Institute means opting for expertise, innovation, and compassionate care. Contact us to schedule a consultation and explore the best fertility solutions for you.
Conclusion
There is no sure shot therapy to improve ovarian function or egg-producing capacity of the ovaries. Any attempt to improve it has limited success. Who will benefit and who will not is not predictable
Time spent for treatment v/s deterioration due to delay in treatment must be kept in mind. A final call should be taken by the patient and the treating doctor.
Stem cells are the patientsтАЩ own cells that have the capacity to transform themselves into different body cells. They are also used for ovarian rejuvenation.
ADVANTAGES
Most commonly, stem cells are derived from patients own body, so there is no risk of transmission of infection. The procedure is relatively very safe. Effective in many cases.
DISADVANTAGES AND LIMITATIONS
Stem cell harvesting is a more invasive process. It is more expensive than PRP. Whether it has better results compared to simpler options like PRP is not proven. Results are variable; all treated patients may not have improvement.
Stem cells are the patientsтАЩ own cells that have the capacity to transform themselves into different body cells. They are also used for ovarian rejuvenation.
ADVANTAGES
Most commonly, stem cells are derived from patients own body, so there is no risk of transmission of infection. The procedure is relatively very safe. Effective in many cases.
DISADVANTAGES AND LIMITATIONS
Stem cell harvesting is a more invasive process. It is more expensive than PRP. Whether it has better results compared to simpler options like PRP is not proven. Results are variable; all treated patients may not have improvement.
FAQs
Results can vary, but improvements in ovarian function may be observed within a few months after treatment.
A balanced diet rich in antioxidants, vitamins, and minerals, such as fruits, vegetables, and whole grains, can support ovarian health.
Ovarian rejuvenation is primarily used for low AMH and poor ovarian reserve but may also benefit other fertility issues by improving overall ovarian function.
Success rates vary widely among patients. Factors such as age and overall health influence outcomes.
Yes, reducing stress, avoiding smoking, limiting alcohol intake, and maintaining a healthy weight can enhance the effectiveness of ovarian rejuvenation.
Treatments can be repeated as needed, but it is important to assess the results and discuss with your doctor to determine the appropriate intervals.
Not all women may benefit from ovarian rejuvenation. Suitability depends on individual health conditions and response to previous treatments.
Generally, ovarian rejuvenation is considered safe, but long-term effects are not fully known. Regular monitoring and follow-ups are essential.
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