Spindle View ICSI
In patients showing poor fertilization with IVF or ICSI, Spindle view ICSI helps to achieve better fertilization. It also provides a more detailed analysis of egg quality.
In eggs, meiotic spindle forms for the final maturation of eggs, During conventional ICSI, when injecting the sperm, we should not damage this spindle to achieve good fertilization.
Spindle view uses a specialized polarized microscope or Polscope to visualize these meiotic spindles.
To achieve better fertilization
Visualizing meiotic spindles can also give an option of aligning oocytes for ICSI. For conventional ICSI, we use the polar body as a surrogate marker for spindle location. In some patients, the spindle is displaced from the polar body, and this can cause potential damage to the spindle at the time of ICSI. If we use polscope and align the spindles, this damage can be minimized. In a study by Elham Asa et al. Fertilization rate in spindle aligned group was higher than the control group.
To assess oocyte egg quality
In patients with repeated poor-quality embryos, there can be factors related to sperm or/and eggs. There are various tests like sperm DNA fragmentation available for evaluating sperm factors apart from conventional semen examination. However, to evaluate oocyte quality presence OR absence of meiotic spindle can be a useful marker. Spindle length and spindle area have also been suggested as a marker of the quality of eggs.
If a couple is considering gamete donation, this information can help the patient decide whether to go for sperm donation OR oocyte donation.
When does Spindle view ICSI help ?
Spindle view ICSI is an advanced micromanipulation technique that uses polarized light microscopy to visualize the meiotic spindle of the oocyte (egg) before injecting the sperm. This allows embryologists to identify the optimal site for sperm injection, potentially improving fertilization outcomes and embryo quality. This technique is particularly helpful in the following situations:
1. Patients showing poor fertilization with IVF or Conventional ICSI
Some patients experience consistently low or failed fertilization rates with traditional IVF or even standard ICSI, despite having seemingly normal sperm and eggs. In such cases, spindle view ICSI offers a more precise approach by allowing the embryologist to avoid damaging the spindle apparatus during sperm injection. Since the spindle plays a key role in proper chromosome alignment and segregation, avoiding damage can improve the chances of successful fertilization and embryo development.
2. Patients who develop poor quality embryos with IVF
Poor embryo quality can be due to multiple factors, including subtle egg abnormalities that are not visible under standard light microscopy. By visualizing the meiotic spindle, embryologists can ensure that sperm is injected in a way that supports optimal oocyte activation and chromosome alignment. This may result in the formation of healthier embryos, offering better prospects for implantation and pregnancy.
3. Patients with very few eggs or Very low AMH levels
In women with low ovarian reserve (very few eggs retrieved or low Anti-Müllerian Hormone – AMH), every egg is precious. Maximizing fertilization rates becomes crucial when egg numbers are limited. Spindle view ICSI minimizes the risk of mechanical or chromosomal damage during the injection process and enhances the likelihood of successful fertilization from each available egg. This tailored approach helps make the most of the limited reproductive potential in such patients.
Why Choose Bavishi Fertility Institute for Spindle View ICSI Treatment ?
- Advanced Reproductive Techniques: Specializing in Spindle View ICSI to improve fertilization outcomes.
- Expert Embryologists: Skilled professionals using the latest technology for precise treatments.
- Cutting-edge Polscope Technology: Allows accurate visualization of the meiotic spindle to reduce the risk of damage.
- Improved Alignment: Ensures better alignment during sperm injection, boosting fertilization success.
- Personalized Care: Tailored treatments to meet the unique needs of each patient.
- Focus on Oocyte Quality: Dedicated to enhancing egg quality for better embryo development.
- Best Outcomes: Committed to providing the highest success rates for couples facing infertility challenges.
Contact Bavishi Fertility Institute today to learn more about how Spindle View ICSI can help you achieve your dreams of parenthood!
For couples seeking a reliable Spindle View ICSI center in Ahmedabad or in cities like Vadodara, Surat, Bhuj & Mumbai Bavishi Fertility Institute is the preferred choice for comprehensive fertility solutions.
FAQs
Conventional ICSI relies on the polar body as a marker for spindle location, whereas Spindle View ICSI uses a Polscope to visualize the actual meiotic spindle, reducing the risk of damage and improving fertilization rates.
Spindle View ICSI uses a specialized polarized microscope to visualize the meiotic spindle in eggs. The embryologist aligns the spindle to avoid damage during sperm injection, improving the chances of fertilization.
Ideal candidates include patients with poor fertilization in previous IVF cycles, poor-quality embryos, or those with a low ovarian reserve (low AMH levels).
Yes, by ensuring that the meiotic spindle is intact during ICSI, Spindle View ICSI can help produce better-quality embryos and improve overall fertilization outcomes.
Spindle View ICSI may have a higher cost due to the specialized technology involved, but it can be more effective for specific patients, potentially saving time and resources in the long term.
Success rates vary depending on individual factors, but studies show that patients undergoing Spindle View ICSI generally experience better fertilization rates compared to conventional ICSI.
The procedure is generally safe, and the use of Polscope technology minimizes the risk of damaging the meiotic spindle, thus improving fertilization chances.
While it can be beneficial for many patients, Spindle View ICSI is particularly recommended for those with a history of poor fertilization or low egg quality in previous cycles.
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