In patients showing poor fertilization with IVF or ICSI, Spindle view ICSI helps to achieve better fertilization. It also provides a more detailed analysis of egg quality.
In eggs, meiotic spindle forms for the final maturation of eggs, During conventional ICSI, when injecting the sperm, we should not damage this spindle to achieve good fertilization.
Spindle view uses a specialized polarized microscope or Polscope to visualize these meiotic spindles.
Visualizing meiotic spindles can also give an option of aligning oocytes for ICSI. For conventional ICSI, we use the polar body as a surrogate marker for spindle location. In some patients, the spindle is displaced from the polar body, and this can cause potential damage to the spindle at the time of ICSI. If we use polscope and align the spindles, this damage can be minimized. In a study by Elham Asa et al. Fertilization rate in spindle aligned group was higher than the control group.
In patients with repeated poor-quality embryos, there can be factors related to sperm or/and eggs. There are various tests like sperm DNA fragmentation available for evaluating sperm factors apart from conventional semen examination. However, to evaluate oocyte quality presence OR absence of meiotic spindle can be a useful marker. Spindle length and spindle area have also been suggested as a marker of the quality of eggs.
If a couple is considering gamete donation, this information can help the patient decide whether to go for sperm donation OR oocyte donation.
Contact Bavishi Fertility Institute today to learn more about how Spindle View ICSI can help you achieve your dreams of parenthood!
Conventional ICSI relies on the polar body as a marker for spindle location, whereas Spindle View ICSI uses a Polscope to visualize the actual meiotic spindle, reducing the risk of damage and improving fertilization rates.
Spindle View ICSI uses a specialized polarized microscope to visualize the meiotic spindle in eggs. The embryologist aligns the spindle to avoid damage during sperm injection, improving the chances of fertilization.
Ideal candidates include patients with poor fertilization in previous IVF cycles, poor-quality embryos, or those with a low ovarian reserve (low AMH levels).
Yes, by ensuring that the meiotic spindle is intact during ICSI, Spindle View ICSI can help produce better-quality embryos and improve overall fertilization outcomes.
Spindle View ICSI may have a higher cost due to the specialized technology involved, but it can be more effective for specific patients, potentially saving time and resources in the long term.
Success rates vary depending on individual factors, but studies show that patients undergoing Spindle View ICSI generally experience better fertilization rates compared to conventional ICSI.
The procedure is generally safe, and the use of Polscope technology minimizes the risk of damaging the meiotic spindle, thus improving fertilization chances.
While it can be beneficial for many patients, Spindle View ICSI is particularly recommended for those with a history of poor fertilization or low egg quality in previous cycles.
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