Ovarian rejuvenation for restoring fertility: A new ray of hope
30 June 2025Ovarian rejuvenation for restoring fertility: A new ray of hope
For many women struggling with infertility due to age or poor ovarian reserve, the dream of parenthood often feels out of reach. But recent advancements in reproductive science offer new hope—Ovarian Rejuvenation Therapy. This innovative treatment aims to reactivate the ovaries’ natural ability to produce eggs, helping women conceive using their own biological material.
Understanding ovarian aging and Diminished ovarian reserve
As a woman ages, her egg quantity and quality gradually decline, especially after the age of 35. In some cases, this decline happens earlier than expected due to:
- Premature ovarian insufficiency (POI).
- Genetic factors.
- Autoimmune disorders.
- Chemotherapy or radiation.
- Lifestyle and environmental factors.
This condition is known as Diminished Ovarian Reserve (DOR)—a major cause of infertility that limits the chances of successful conception even with assisted reproductive techniques like IVF.
What is ovarian rejuvenation therapy?
Ovarian rejuvenation is a regenerative treatment that stimulates dormant ovarian follicles, aiming to enhance natural hormone production and egg development. The most commonly used technique involves Platelet-Rich Plasma (PRP) therapy, though other emerging approaches are also under study.
In PRP-based ovarian rejuvenation:
- A small amount of the patient’s blood is drawn.
- Platelet-rich plasma, which contains growth factors and healing properties, is extracted and activated.
- This PRP is then carefully injected into the ovaries under ultrasound guidance.
The goal is to awaken resting follicles, promote new egg development, and restore ovarian function.
Who is a candidate for ovarian rejuvenation?
This therapy may be considered for women who:
- Have poor ovarian reserve or high FSH/low AMH levels.
- Are approaching menopause
- Have a history of failed IVF cycles with poor egg response.
- Want to try conceiving using their own eggs before considering egg donation.
It’s important to note that not all women are eligible, and a thorough evaluation is required to determine if this therapy is appropriate.
Benefits of ovarian rejuvenation
- May improve hormone levels (like AMH and estrogen).
- Could lead to natural ovulation.
- Potential to retrieve more eggs during IVF cycles.
- Offers a chance to conceive with their own biological eggs.
- Minimally invasive and safe, using the patient’s own blood.
Step-by-Step process of PRP treatment for ovarian rejuvenation
Pre-treatment evaluation:
- Blood tests (AMH, FSH, LH, Estradiol).
- Ultrasound to assess antral follicle count.
- Medical history review and fertility counseling.
- Blood tests (AMH, FSH, LH, Estradiol).
PRP collection and Preparation:
- Blood is collected and centrifuged to isolate platelet-rich plasma.
- Blood is collected and centrifuged to isolate platelet-rich plasma.
Ovarian injection:
- PRP is injected into each ovary using a transvaginal ultrasound-guided needle.
- The procedure is done under mild sedation or local anesthesia.
- PRP is injected into each ovary using a transvaginal ultrasound-guided needle.
Post-Procedure monitoring:
- Hormone levels are monitored over the next few weeks.
- Follicular growth is assessed via ultrasound.
- Patients may then proceed to natural conception attempts or IVF cycles depending on the ovarian response.
- Hormone levels are monitored over the next few weeks.
Success rates and Expectations
While ovarian rejuvenation is still an evolving therapy, early research and clinical results are promising. Some women have reported:
- Resumption of menstrual cycles.
- Improved hormone profiles.
- Better ovarian response in IVF.
- Successful pregnancies.
However, results can vary based on age, initial ovarian reserve, and individual response. At Bavishi Fertility Institute, we ensure every patient receives realistic counseling and personalized treatment plans.
Ovarian rejuvenation vs. Egg donation: Which one is right for you?
For women with severely diminished ovarian reserve, egg donation is often recommended due to higher success rates. However, ovarian rejuvenation offers an intermediate step—a chance to try with your own eggs first.
Our expert team helps couples understand:
- The chances of success with each option.
- Emotional and ethical considerations.
- Time sensitivity and overall fertility goals.
Why choose Bavishi Fertility Institute for ovarian rejuvenation?
At Bavishi Fertility Institute, we combine expertise, innovation, and empathy to deliver world-class fertility care. Here’s why patients trust us:
- Experienced team of fertility specialists with expertise in advanced reproductive technologies.
- Comprehensive diagnostic evaluation and counseling.
- Personalized treatment protocols based on your fertility profile.
- Transparent discussion about success rates, expectations, and alternatives.
- High standards of safety, ethics, and patient care.
Take the first step toward parenthood
If you’ve been told you have poor egg quality or low ovarian reserve, don’t give up hope. Ovarian rejuvenation could offer you a renewed chance at motherhood.
Conclusion
Ovarian rejuvenation represents a groundbreaking advancement in fertility care—offering renewed hope to women with diminished ovarian reserve or age-related infertility. While still an evolving therapy, it provides a promising alternative to egg donation, especially for those who wish to conceive using their own eggs. At Bavishi Fertility Institute, we are committed to walking this journey with you—combining cutting-edge science with compassionate care to help you achieve your dream of parenthood. Contact Bavishi Fertility Institute now and begin your journey to parenthood with confidence and care.
Author bio
Dr. Parth Bavishi
Dr. Parth Bavishi, MD in Obstetrics and Gynecology, brings over 12 years of invaluable work experience to his role as Director of Bavishi Fertility Institute, leading a group of IVF clinics committed to helping couples realise their dreams of parenthood.
Bavishi Fertility Institute is dedicated to providing customised and personalised treatments which are simple, safe , smart and successful. Bavishi Fertility Institute works with success and satisfaction for all at heart. Providing an ideal blend of professional treatment and personalised care.
Dr Parth had special training in infertility at Bavishi fertility Institute, the Diamond Institute, USA, and the HART Institute, Japan.
Dr. Bavishi is a distinguished expert in his field. In addition to his clinical practice, Dr. Bavishi is the author of the acclaimed book, ‘Your Miracle in Making: A Couple’s Guide to Pregnancy,’ offering invaluable insights to couples navigating the complexities of fertility. He loves to empower patients to make the correct choice by education both online and offline.
His exceptional contributions have earned him the prestigious Rose of Paracelsus award from the European Medical Association. Dr Parth has been an invited faculty at many national and international conferences.
Beyond his professional endeavors, Dr. Bavishi is an avid traveller who finds solace in exploring new destinations. He also enjoys engaging his mind with brainy puzzles, always seeking new challenges and solutions outside of the medical realm.
FAQs
Yes, even without regular periods, ovulation can still occur sporadically. With tracking and treatment, pregnancy is possible.
Most patients report only mild discomfort. The procedure is performed under local anesthesia or mild sedation, making it generally well-tolerated.
The rejuvenation effect varies between individuals, but some women may see improvements lasting several months. Repeat treatments may be considered depending on the response.
Typically, fertility specialists monitor hormone levels and follicular development for 0–2 cycles before recommending natural conception attempts or IVF.
In select cases, yes. While results are more limited in women with POI, some studies and reports show restored ovarian function. Candidacy is determined through detailed evaluation. In women who have had no menses for 6 months and are not taking any treatment the potential for improvement is less.
PRP is derived from your own blood, making it a low-risk procedure. However, minor side effects such as cramping or spotting may occur. Serious complications are rare.
Ovarian rejuvenation is currently considered an experimental therapy in many countries, including India. It is offered under ethical clinical practices with informed consent.
Yes, depending on your initial response and fertility goals, repeat sessions may be planned after clinical assessment.
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