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Can IVF Work with Low AMH?

Can IVF Work with Low AMH?

19 June 2024

Can IVF Work with Low AMH?

Anti-Mullerian Hormone (AMH) plays a crucial role in assessing a woman’s ovarian reserve and fertility. Low AMH levels can be a concern for women trying to conceive, as it often indicates a lower egg quantity. Despite this challenge, In Vitro Fertilization (IVF) can be a viable option for women with Low AMH. Let’s explore how IVF works in the context of Low AMH and the strategies to improve success rates.

Understanding Low AMH

Although a common test, there is no clearly defined  cut-off value of low AMH . Values of 0 .5 to 2.2 ng/ml have been considered as a cut-off value for low AMH. According to recent and commonly followed POSEIDON criteria AMH cutoff value of 1.2 ng/ml is considered as standard cutoff value for low AMH. Several factors can contribute to low AMH, including age, genetics, medical conditions, medicines and lifestyle. The condition may affect the quantity and quality of eggs produced, leading to reduced fertility.

The Impact of Low AMH on Fertility

Low AMH can have a direct impact on natural conception. It may result in fewer viable eggs and a decreased chance of successful pregnancy. Women with Low AMH might experience earlier menopause and have fewer opportunities to conceive naturally.

Can IVF work with Low AMH?

IVF can be effective for women with Low AMH, though the success rate might be slightly lower than in women with normal AMH levels. Success with IVF in women with Low AMH depends on several factors:

  • Age: Younger women with low AMH often have better outcomes, as egg quality tends to be higher.

  • Overall health: Women in good health can respond better to stimulation protocols and have a higher success rate.

  • Previous fertility treatments: Women who have undergone unsuccessful fertility treatments might benefit from a more customized IVF protocol.

Case studies have shown that women with Low AMH can achieve successful pregnancies through IVF, particularly with personalized treatment plans and advanced techniques like Pre-implantation Genetic Testing (PGT).

Strategies to improve IVF Success with Low AMH

1. Personalized IVF protocols:

  • Adjusting medication dosages and stimulation protocols can increase ovarian response.
  • Monitoring closely during the IVF cycle can provide better management.

2. Pre-implantation Genetic Testing (PGT):

  • PGT can help identify viable embryos with higher chances of successful implantation.
  • This advanced technique ensures that only the healthiest embryos are selected for transfer.

3. Donor eggs:

  • In some cases, using donor eggs can provide a better chance of a successful pregnancy.
  • This option can be discussed as an alternative for women with severe Low AMH.

4. Timing and Monitoring:

  • Close monitoring during IVF cycles allows adjustments to medication and stimulation protocols.
  • This approach maximizes egg production and quality.

Lifestyle and Dietary Changes to Support IVF with Low AMH

  • Diet: A balanced diet rich in antioxidants, vitamins, and minerals can help support egg health.

  • Exercise: Regular, moderate exercise can improve overall health and fertility.

  • Stress management: Techniques like yoga, meditation, and mindfulness can reduce stress and enhance overall well-being.

  • Supplements and Vitamins: Certain supplements like Coenzyme Q10 (CoQ10), Vitamin D, and Omega-3 fatty acids can improve egg quality.

Emotional and Psychological Support

A diagnosis of Low AMH can bring emotional and psychological stress. It’s essential to seek emotional support from fertility counsellors, support groups, or therapy. Managing stress effectively through mindfulness practices can significantly improve the chances of successful IVF treatment.

Conclusion

IVF can indeed work with Low AMH, but success rates can vary. Personalized treatment plans, lifestyle changes, and emotional support can greatly improve outcomes. Bavishi Fertility Institute offers comprehensive consultation and support for individuals and couples exploring IVF with Low AMH.

If you or someone you know is facing challenges with Low AMH and considering IVF, schedule a consultation with Bavishi Fertility Institute. Our team is committed to guiding you through your journey to parenthood.

Author Bio

Dr. Parth Bavishi

Dr. Parth Bavishi, MD in Obstetrics and Gynecology, brings over 12 years of invaluable work experience to his role as Director of Bavishi Fertility Institute, leading a group of IVF clinics committed to helping couples realise their dreams of parenthood. 

Bavishi Fertility Institute is dedicated to provide customised and personalised treatments which are simple, safe , smart and successful. Bavishi Fertility Institute works with success and satisfaction for all at heart. Providing an ideal blend of professional treatment and personalised care.

Dr Parth had special training in infertility at Bavishi fertility Institute, the Diamond Institute, USA, and the HART Institute, Japan.

Dr. Bavishi is a distinguished expert in his field. In addition to his clinical practice, Dr. Bavishi is the author of the acclaimed book, ‘Your Miracle in Making: A Couple’s Guide to Pregnancy,’ offering invaluable insights to couples navigating the complexities of fertility. He loves to empower patients to make the correct choice by education both online and offline .

His exceptional contributions have earned him the prestigious Rose of Paracelsus award from the European Medical Association. Dr Parth has been an invited faculty at many national and international conferences.

Beyond his professional endeavors, Dr. Bavishi is an avid traveller who finds solace in exploring new destinations. He also enjoys engaging his mind with brainy puzzles, always seeking new challenges and solutions outside of the medical realm.

FAQs

It may be more challenging to conceive naturally, but many women with low AMH have still successfully conceived. IVF offers a higher chance of achieving pregnancy in such cases.

As a general guideline from the author you should consider achieving pregnancy in maximum one calendar year either naturally or with treatment. 

Lifestyle changes, supplements, and holistic treatments like acupuncture can support egg health. Additionally, donor eggs can be a viable option.

Other regenerative therapies like ovarian PRP may also improve egg count.

This decision should be made after consulting with your fertility specialist, considering your health, ovarian reserve, and treatment goals.

Trying IVF with your eggs does not reduce the success rate of future Donor eggs cycles. So if you wish to achieve pregnancy with your own eggs,, you should definitely try as there is no or minimal long-term complication associated.

Success rates vary based on various factors, including age, health, and overall ovarian response. Generally, women with low AMH have lower success rates compared to those with normal AMH, but with personalized treatment plans, many women achieve successful pregnancies.

IVF can still be possible with very low AMH levels, but success rates may be lower. A thorough consultation with a fertility specialist can help determine the most suitable treatment plan. Thousands of women have conceived with IVF with a level as low as 0.5 or lower. You should definitely not give up hope.

No AMH levels do not  decline after ovarian stimulation during IVF. Stimulation in Ivf, recruit the follicles or eggs from that particular cycle, only. It does not affect future egg count or ovarian reserve egg count or ovarian reserve. If you don’t go for ovarian stimulation, those follicles are destined to regress on their own.

Fertility medications, such as gonadotropins, can be tailored to individual needs to improve ovarian response. These medications can encourage the growth of multiple follicles, thereby enhancing the chances of a successful IVF cycle.

Some nutritional supplements may improve egg count, however, their effectiveness is limited.

Medical conditions such as thyroid disorders, or autoimmune diseases can influence IVF success rates. It’s essential to discuss these conditions with your fertility specialist to develop a tailored treatment plan.

Emotional well-being plays a significant role in IVF outcomes. High stress levels can negatively affect hormonal balance and reproductive health. Managing stress through mindfulness practices, therapy, and support groups can contribute to better outcomes.

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