Miscarriages during IVF: Signs, Causes, Prevention and Hope

Miscarriages during IVF: Signs, Causes, Prevention and Hope

29 January 2024

Miscarriages during IVF: Signs, Causes, Prevention and Hope

Embarking on the fertility journey is a testament to your courage and commitment towards building a family. However, we acknowledge that the possibility of a miscarriage during IVF can introduce unexpected challenges and emotional stress. 

In this blog, we aim to provide a heartfelt and informative guide to help you understand, cope, and navigate the complexities of miscarriages during IVF.

What is Miscarriage?

A miscarriage refers to the spontaneous loss of a pregnancy before the 20th week. While the emotional toll is significant, it’s important to note that it’s a common occurrence, even in couples undergoing In Vitro Fertilization (IVF). Miscarriages can happen for various reasons, and they are not necessarily an indication of future fertility challenges.

Recognizing Signs of Miscarriage during IVF

  1. Vaginal Bleeding: One of the most common signs of miscarriage is vaginal bleeding. While some spotting may be normal, persistent or heavy bleeding should be promptly addressed.

  2. Abdominal Pain: Cramping and abdominal pain can also indicate a potential miscarriage. If the pain is severe or persistent, seeking medical attention is crucial.

  3. Decreased Pregnancy Symptoms: A sudden decrease in pregnancy symptoms, such as breast tenderness or nausea, may suggest a miscarriage. However, it’s important to note that symptoms can vary for each individual.

Causes of Miscarriage during IVF

Some possible causes of miscarriage during IVF include:

  1. Chromosomal Abnormalities: One of the most common reasons for miscarriage is chromosomal abnormalities in the developing embryo. This can happen during fertilization or in the early stages of cell division. Advanced maternal age is often associated with an increased risk of chromosomal abnormalities.

  2. Embryo Quality: The quality of the embryos used in IVF plays a crucial role. If the embryos are not of optimal quality, they may not implant or develop properly, leading to miscarriage.

  3. Implantation Issues: Successful implantation of the embryo into the uterus lining is essential for a pregnancy to progress. Problems with implantation, such as a weak uterine lining or improper embryo positioning, can result in miscarriage.

  4. Uterine Abnormalities: Structural abnormalities in the uterus, such as
    fibroids or septum, can interfere with implantation and increase the risk of miscarriage.

  5. Hormonal Imbalances: Hormonal imbalances, including those related to the levels of progesterone, estrogen, and thyroid hormones, can impact the success of implantation and the maintenance of pregnancy.

  6. Immunological Factors: An inappropriate immune response may lead to the rejection of the embryo. Some women may have an overactive immune system that perceives the embryo as a foreign body.

  7. Lifestyle Factors: Certain lifestyle factors, such as smoking, excessive alcohol consumption, and a high level of stress, can negatively impact fertility and contribute to miscarriage.

  8. Blood Clotting Disorders: Some women may have blood clotting disorders that increase the risk of clot formation in the placenta, reducing blood flow to the developing embryo and leading to miscarriage.

  9. Infection: Infections, whether bacterial or viral, can pose a risk to the developing embryo and may result in miscarriage.

  10. Genetic Factors: Both partners may carry genetic factors that increase the risk of miscarriage. Genetic testing can help identify potential issues.

Most of the above factors are common for miscarriages during natural conception or with Ivf.

Preventive measures to take to avoid miscarriages during IVF

Preventing miscarriages during IVF involves addressing various factors that could contribute to pregnancy loss. Here are some general preventive measures that may be discussed:

  1. Thorough Screening: Prior to undergoing IVF, both partners should undergo comprehensive screening for any underlying health issues, infections, or genetic conditions that could affect pregnancy.

  2. Optimizing Lifestyle Factors: Ensure a well-balanced diet with adequate vitamins and minerals. Maintain a healthy weight, as both underweight and overweight conditions can impact fertility. Eliminate smoking, excessive alcohol intake, and illicit drug use, as these can negatively affect fertility and increase the risk of miscarriage.

  3. Addressing Hormonal Imbalances: Work with your healthcare provider to address any hormonal imbalances that may be contributing to fertility issues.

  4. Managing Chronic Conditions: If you have chronic health conditions such as diabetes or thyroid disorders, ensure they are well-managed and controlled.

  5. Stress Management: Engage in stress-reducing activities such as yoga, meditation, or counseling, as high stress levels may impact fertility.

  6. Supportive Medications: Your healthcare provider may prescribe medications such as progesterone supplements to support the early stages of pregnancy.

  7. Regular Check-ups and Monitoring: Schedule regular check-ups and ultrasounds to closely monitor the progress of the pregnancy and address any concerns promptly.

  8. Immunological Factors: Some couples may explore immunological testing and treatments if there are concerns about immune system responses affecting pregnancy.

  9. Thrombophilia Testing: In cases where there’s a history of blood clotting disorders, thrombophilia testing may be considered.

  10. Pre-implantation Genetic Testing (PGT): Considering pre-implantation genetic testing on embryos before implantation may help identify and select embryos with a lower risk of chromosomal abnormalities. This technique is particularly useful in advanced maternal age.

Does Miscarriage Affect Fertility Permanently?

One common concern among couples who experience miscarriage after IVF is whether it has a lasting impact on fertility. The good news is that a single miscarriage, in most cases, does not necessarily indicate a permanent impairment of fertility. 

Seeking guidance from fertility specialists, understanding the root cause, and implementing appropriate interventions can help couples move forward with renewed hope.

How Soon After Miscarriage Can We Try Again?

The timing to try again after a miscarriage during IVF can vary based on individual circumstances and the specific details of the miscarriage. Generally, doctors may recommend waiting a few weeks to a few months before attempting another IVF cycle. This allows time for the body to recover physically and emotionally. As a general principle waiting for three months before trying again is good.

Factors influencing the recommended wait time may include the cause of the miscarriage, any necessary medical treatments, and the overall health of the individual. Emotional readiness is also a crucial consideration, as going through a miscarriage can be a challenging experience.

Your fertility specialist will be the best person to guide you on the appropriate timing for your specific situation. They can assess your medical history, conduct necessary tests, and provide personalized recommendations based on your unique circumstances.


Embarking on the IVF journey is a brave step towards realizing the dream of parenthood. Miscarriage, though a challenging aspect of this journey, does not define its entirety. By recognizing signs, understanding causes, and implementing preventive measures, couples can navigate the complexities of fertility treatments with resilience and hope. The journey may be difficult, but with the right support and information, the path to parenthood can still be illuminated with the promise of new beginnings. 

At Bavishi Fertility Institute, we are here to support you every step of the way. If you have questions, concerns, or if you’re ready to take the next step in your fertility journey, contact us today. Our dedicated team is committed to providing personalized care to help you achieve your dream of parenthood. Remember, each journey is unique, and with the right support, success is possible.

Author Bio

Dr. Parth Bavishi

Dr. Parth Bavishi, MD in Obstetrics and Gynecology, brings over 12 years of invaluable work experience to his role as Director of Bavishi Fertility Institute, leading a group of IVF clinics committed to helping couples realise their dreams of parenthood. 

Bavishi Fertility Institute is dedicated to providing customised and personalised treatments which are simple, safe , smart and successful. Bavishi Fertility Institute works with success and satisfaction for all at heart. Providing an ideal blend of professional treatment and personalised care.

Dr Parth had special training in infertility at Bavishi fertility Institute, the Diamond Institute, USA, and the HART Institute, Japan.

Dr. Bavishi is a distinguished expert in his field. In addition to his clinical practice, Dr. Bavishi is the author of the acclaimed book, ‘Your Miracle in Making: A Couple’s Guide to Pregnancy,’ offering invaluable insights to couples navigating the complexities of fertility. He loves to empower patients to make the correct choice by education both online and offline .

His exceptional contributions have earned him the prestigious Rose of Paracelsus award from the European Medical Association. Dr Parth has been an invited faculty at many national and international conferences.

Beyond his professional endeavors, Dr. Bavishi is an avid traveller who finds solace in exploring new destinations. He also enjoys engaging his mind with brainy puzzles, always seeking new challenges and solutions outside of the medical realm.

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